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The clinical trial evidence is now so strong (STEP, SURMOUNT, SELECT trials) that more payers are adding GLP-1 coverage
(12, 13) By improving glycemic control, enhancing insulin sensitivity, and reducing adiposity, GLP-1 therapies may decrease bone marrow adipose tissue (BMAT) formation and mitigate the harmful effects of hyperglycemia on bone quality
Minakova E, et al
Prolonged disruption of lysosomal function can trigger compensatory programs, including autophagy rewiring, enhanced lysosomal biogenesis driven by transcription factor EB (TFEB) nuclear translocation, and activation of stress-response pathways such as the unfolded protein response and oxidative stress adaptation
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